Catalog-specification |
Delivery time |
USD price |
abs44063307-200ug |
4 weeks |
180 |
abs44063307-1mg |
In Stock |
447 |
abs44063307-10mg |
4 weeks |
3383 |
Attention: the price only for your reference, the detail price please contact our seller Vecent.
Overview | |
Description |
Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait†region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes. |
Other names |
人α-2 Macroglobulin; A2M; Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086. |
Source |
Human Plasma |
MW |
725 kDa |
Appearance |
Sterile Filtered White lyophilized (freeze-dried) powder |
Properties | |
Concentration |
96% |
Stability & Storage |
Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8℃. Do not freeze! |
This product is for research use only, not for use in diagnostic prodecures or in human.
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